Using NGS to detect NTRK gene fusions

Currently, there are several different molecular testing methods that may be used to detect NTRK gene fusions. NGS can be used to identify NTRK gene fusions as well as other actionable alterations. It is important to know whether the NGS assay used has the capacity to detect NTRK gene fusions.

According to the drug manufacturers, the following NGS testing platforms use assays that can detect NTRK gene fusions:

• Caris Life Sciences
• Foundation Medicine
• Integrated Oncology (LabCorp)/OmniSeq
• NAVICAN
• NeoGenomics Laboratories
• Paradigm Diagnostics
• PathGroup
• Tempus

NGS, next-generation sequencing; NTRK, neurotrophic receptor tyrosine kinase.